Daniel Boone High School opened in 1971-1972 to serve the students of the northern half of Washington County. Its feeder schools are Boones Creek Middle, Gray Elementary, Fall Branch Elementary, Ridgeview Elementary, and Sulphur Springs Elementary schools. The school is located near several colleges, universities, and libraries; which provide opportunities for the students.

Daniel Boone's enrollment has been steadily rising for the last few years, remaining between 1100 and 1400 students.